Nanotechnology Meets Stem Cell Therapy for Treating Glioblastomas: A Review

Abstract

Malignant glioblastoma, also known as Glioblastoma multiforme (GBM), is one of the most aggressive subtypes, characterized by wide vascularization and complex invasion. The currently available standard care for GBM includes maximal surgical resection, radiotherapy, and chemotherapy. These standard therapeutic procedures are facilitating the treatment by means of prolonging the lifetime. However, these processes cannot prevent tumor recurrence in the future and thereby compromise the patient lifetime. This disease recurrence is accredited to the presence of glioma stem cells (GSCs) that are resistant toward chemo and radiation therapies. GSCs are mainly associated with vascular niches that control GSC self-renewal and survival. Therefore, targeting of GSCs using various nanoparticle-assisted therapeutics may improve the efficacy of the drugs used alone or in combination that may result in progress in patient survival.

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