J Transl Med. 2010 Aug 20;8:77. Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke. Sun C, Zhang H, Li J, Huang H, Cheng H, Wang Y, Li P, An Y. Source Department of Neural Stem Cell, Beijing Neurosurgical Institute, Beijing Tiantan…

Brain Res. 2010 Dec 17;1366:217-25. Epub 2010 Oct 1. Intravenous infusion of GDNF gene-modified human umbilical cord blood CD34+ cells protects against cerebral ischemic injury in spontaneously hypertensive rats. Ou Y, Yu S, Kaneko Y, Tajiri N, Bae EC, Chheda SH, Stahl CE, Yang T, Fang L, Hu K, Borlongan CV, Yu G. Source Department…

J Neurosci Res. 2010 Nov 15;88(15):3282-94. Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model. Lee HJ, Lim IJ, Lee MC, Kim SU. Source Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea. Abstract Intracerebral hemorrhage (ICH) is a lethal stroke type;…

CNS Neurol Disord Drug Targets. 2011 Mar;10(2):215-34. Critical questions for preclinical trials on safety and efficacy of vascular endothelial growth factor-based therapeutic angiogenesis for ischemic stroke. Manoonkitiwongsa PS. Source Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, CA, USA. stevemanoon@hotmail.com Abstract Therapeutic angiogenesis is a novel treatment for ischemic stroke, and vascular endothelial growth factor…

Gene Ther. 2011 Jan;18(1):1-6. Epub 2010 Sep 30. Progress and prospects: stem cells and neurological diseases. Gögel S, Gubernator M, Minger SL. Source Wolfson Centre for Age-Related Diseases, Guy’s Campus, King’s College London, London, UK. stefanie.gogel@kcl.ac.uk Abstract The central nervous system has limited capacity of regenerating lost tissue in slowly progressive, degenerative neurological conditions such…

Cell Transplant. 2011;20(1):95-7. Epub 2010 Sep 30. Vascular protection and restorative therapy in ischemic stroke. Yamashita T, Deguchi K, Nagotani S, Abe K. Source Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Abstract Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring…

Stem Cells. 2008 Sep;26(9):2217-28. Epub 2008 Jul 10. Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain. Kim SS, Yoo SW, Park TS, Ahn SC, Jeong HS, Kim JW, Chang DY, Cho KG, Kim SU, Huh Y, Lee JE, Lee SY, Lee YD, Suh-Kim H. Source Department of…