Stem Cell Research Studies

Overlapping juvenile idiopathic arthritis and systemic lupus erythematosus: a case report.

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Rheumatol Int. 2010 Jul 30; Authors: Bazsó A, Sevcic K, Orbán I, Poór G, Balogh Z, Kiss E Hereby, we report the case of a 12-year-old girl developing oligoarthritis and progressing into a polyarticular form. Rheumatoid factor was positive, and juvenile idiopathic arthritis (JIA) was diagnosed. After a poor response to DMARDs, an anti-TNF agent…

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Mesenchymal stem cells in arthritis: role of bone marrow microenvironment.

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Arthritis Res Ther. 2010;12(4):135 Authors: Jorgensen C Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSCs) are intensively studied for regenerative medicine. Moreover, MSCs are potent immunomodulatory cells that occur through the secretion of soluble mediators including nitric oxide, transforming growth factor beta, and HLAG5. The MSCs, however, are also able…

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Does the KIR2DS5 gene protect from some human diseases?

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PLoS One. 2010;5(8):e12381 Authors: Nowak I, Majorczyk E, WiÅ›niewski A, Pawlik A, Magott-Procelewska M, Passowicz-MuszyÅ„ska E, Malejczyk J, PÅ‚oski R, Giebel S, Barcz E, ZoÅ„-Giebel A, Malinowski A, Tchórzewski H, Chlebicki A, Łuszczek W, Kurpisz M, GryboÅ› M, WilczyÅ„ski J, Wiland P, Senitzer D, Sun JY, Jankowska R, Klinger M, KuÅ›nierczyk P BACKGROUND: KIR2DS5 gene…

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A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke.

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Cells. 2010 Jun;28(6):1099-106 A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. • Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY, • We previously evaluated the short-term follow-up preliminary data of mesenchymal stem cells (MSCs) transplantation in patients with ischemic stroke. The present study…

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• Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats.

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• J Transl Med. 2010;8:63 • Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. • Leu S, Lin YC, Yuen CM, Yen CH, Kao YH, Sun CK, Yip HK • BACKGROUND: The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status…

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Stem cell transplantation for ischemic stroke.

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Cochrane Database Syst Rev. 2010;9:CD007231 Stem cell transplantation for ischemic stroke. Boncoraglio GB, Bersano A, Candelise L, Reynolds BA, Parati EA BACKGROUND: Studies in animal models of ischemic stroke have shown that stem cells transplanted into the brain can lead to functional improvement. However, to date, evidence for the benefits of stem cell transplantation in…

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Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with trophic factors.

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J Neurol Sci. 2010 Sep 21; Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with trophic factors. Choi YJ, Li WY, Moon GJ, Lee PH, Ahn YH, Lee G, Bang OY BACKGROUND: Several studies have examined the enhanced efficacy of mesenchymal stem cells (MSCs) using neurotrophic factor transfection in ischemic rat models.…

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Stem cells in human neurodegenerative disorders–time for clinical translation?

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J Clin Invest. 2010 Jan 4;120(1):29-40 Stem cells in human neurodegenerative disorders–time for clinical translation? Lindvall O, Kokaia Z Stem cell-based approaches have received much hype as potential treatments for neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in animal models of neurodegenerative diseases can improve function by replacing the lost neurons and…

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The potential of mesenchymal stem cells for neural repair.

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Discov Med. 2010 Mar;9(46):236-42. The potential of mesenchymal stem cells for neural repair. Miller RH, Bai L, Lennon DP, Caplan AI. Source Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. rhm3@case.edu Abstract Developing effective therapies for serious neurological insults remains…

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Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis.

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Brain Res. 2010 Jun 2;1334:65-72. Epub 2010 Mar 28. Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis. Li J, Zhu H, Liu Y, Li Q, Lu S, Feng M, Xu Y, Huang L, Ma C, An Y, Zhao RC, Wang R, Qin C. Source Institute of Laboratory…

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