Cell Adh Migr. 2010 Apr-Jun;4(2):235-40 Adult human mesenchymal cells proliferate and migrate in response to chemokines expressed in demyelination. Rice CM, Scolding NJ Abstract Systemic delivery of multipotent mesenchymal stem cells (MSC) may be of benefit in the treatment of neurological diseases, including multiple sclerosis (MS). Certainly, animal studies have demonstrated functional benefits following MSC…

2010 Mar; 9(46) : 236-42. The potential of mesenchymal stem cells for neural repair. Miller RH, Bai L, Lennon DP, Caplan AI. Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. rhm3@case.edu Abstract Developing effective therapies for serious neurological insults remains…

2010 Feb; 45(2) : 239-48 Brazilian experience with two conditioning regimens in patients with multiple sclerosis: BEAM/horse ATG and CY/rabbit ATG. Hamerschlak N, Rodrigues M, Moraes DA, Oliveira MC, Stracieri AB, Pieroni F, Barros GM, Madeira MI, SimAμes BP, Barreira AA, Brum DG, Ribeiro AA, Kutner JM, Tylberi CP, Porto PP, Santana CL, Neto JZ,…

2010 Jan;6(1):77-88 Update on the treatment options for multiple sclerosis. Niino M, Sasaki H Abstract Recent progress in the treatment of multiple sclerosis (MS) is remarkable, and the introduction of new therapies is yielding improvements in the management of MS. Furthermore, clinical trials with many different types of agents, especially selected monoclonal antibodies, have been…

2010; 51 : 237-57 Immuno-therapeutic potential of haematopoietic and mesenchymal stem cell transplantation in MS. Muraro PA, Uccelli A Abstract In the last few years there has been extraordinary progress in the field of stem cell research. Two types of stem cells populate the bone marrow: haematopoietic stem/progenitor cells (HSC) and mesenchymal stem cells (MSC).…

2009 Dec;9(12):1487-97 Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases. Sadan O, Melamed E, Offen D Abstract BACKGROUND: Stem-cell-based therapy is a promising new approach to handling neurodegenerative diseases. One of the most promising cellular sources is bone-marrow-derived mesenchymal stem cells (MSCs) also termed multipotent stromal cells. MSCs represent an autologous source and are abundant…

2009; 51(1) : 24-41 Preclinical assessment of stem cell therapies for neurological diseases. Joers VL, Emborg ME Abstract Stem cells, as subjects of study for use in treating neurological diseases, are envisioned as a replacement for lost neurons and glia, a means of trophic support, a therapeutic vehicle, and, more recently, a tool for in…

2009 Nov;9(8):992-1016 Stem cell and gene therapeutic strategies for the treatment of multiple sclerosis. Siatskas C, Bernard CC Abstract Multiple sclerosis is a disease of the central nervous system that predominantly affects young adults. The pathogenic mechanisms are complex, however numerous studies indicate that the disease is initiated by an autoimmune attack on protein targets…

2009 Oct; 27(10) : 2624-35 Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis. Constantin G, Marconi S, Rossi B, Angiari S, Calderan L, Anghileri E, Gini B, Bach SD, Martinello M, Bifari F, Galiè M, Turano E, Budui S, Sbarbati A, Krampera M, Bonetti B Abstract Mesenchymal stem cells (MSCs) represent a promising therapeutic…

2009 Sep;110(5):1674-84 Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. Lanza C, Morando S, Voci A, Canesi L, Principato MC, Serpero LD, Mancardi G, Uccelli A, Vergani L Abstract Experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis, is characterized by demyelination, inflammation and neurodegeneration of CNS in…