Zhonghua Wai Ke Za Zhi. 2008 Apr 1;46(7):493-6 Authors: Zhang P, Gan YK, Tang J, Hao YQ, Wang Y, Sun YH, Zhu ZA, Dai KR OBJECTIVE: To explorer the effectiveness of enriched bone marrow stem cells technique for lumbar fusion. METHODS: With the randomization and control principles, 2 graft materials [Enrichment bone marrow mesenchymal stem…

J Orthop Res. 2009 Mar;27(3):374-9 Authors: Wei A, Tao H, Chung SA, Brisby H, Ma DD, Diwan AD Intervertebral disc degeneration is a major cause and a risk factor for chronic low back pain. The potential of using stem cells to treat disc degeneration has been raised. The aims of our study were to assess…

Cell Mol Biol (Noisy-le-grand). 2008;54(1):24-32 Authors: Hiyama A, Mochida J, Sakai D There is increasing rise of interest in stem cell therapy, as it provides new options for treating a broad range of diseases. Several experimental methods are being explored for the use of stem cells in delaying or reversing the degenerative process of the…

Eur Spine J. 2008 Dec;17 Suppl 4:480-91 Authors: Kandel R, Roberts S, Urban JP Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers’ compensation benefits is significant. Surgical intervention as practised…

Eur Spine J. 2008 Dec;17 Suppl 4:452-8 Authors: Sakai D. Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biological therapy to treat disc disease without reducing the mobility of the spinal…

Spine (Phila Pa 1976). 2009 Jan 15;34(2):141-8 Authors: Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A, Brisby H STUDY DESIGN: Experimental and descriptive study of a xenotransplantation model in minipigs. OBJECTIVE: To study survival and function of human mesenchymal stem cells (hMSCs) after transplantation into injured porcine spinal discs, as a…

Biochem Biophys Res Commun. 2009 Feb 20;379(4):824-9 Authors: Wuertz K, Godburn K, Iatridis JC Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague-Dawley rats…

Arthritis Res Ther. 2009;11(1):R20 Authors: Le Maitre CL, Baird P, Freemont AJ, Hoyland JA INTRODUCTION: The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for…

Spine (Phila Pa 1976). 2009 Mar 1;34(5):E178-82 Authors: Peng B, Chen J, Kuang Z, Li D, Pang X, Zhang X STUDY DESIGN: We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study the histopathological features and connective tissue growth factor (CTGF) expressions. OBJECTIVE: To study the expression and…

J Neurosurg Spine. 2009 Mar;10(3):265-72 Authors: Sheikh H, Zakharian K, De La Torre RP, Facek C, Vasquez A, Chaudhry GR, Svinarich D, Perez-Cruet MJ OBJECT: There is currently no biologic therapy to repair or restore a degenerated intervertebral disc. A potential solution may rest with embryonic stem cells (ESCs), which have a potential to grow…