Auto-Immune Diseases Library

Overlapping juvenile idiopathic arthritis and systemic lupus erythematosus: a case report.

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Rheumatol Int. 2010 Jul 30; Authors: Bazsó A, Sevcic K, Orbán I, Poór G, Balogh Z, Kiss E Hereby, we report the case of a 12-year-old girl developing oligoarthritis and progressing into a polyarticular form. Rheumatoid factor was positive, and juvenile idiopathic arthritis (JIA) was diagnosed. After a poor response to DMARDs, an anti-TNF agent…

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Mesenchymal stem cells in arthritis: role of bone marrow microenvironment.

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Arthritis Res Ther. 2010;12(4):135 Authors: Jorgensen C Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSCs) are intensively studied for regenerative medicine. Moreover, MSCs are potent immunomodulatory cells that occur through the secretion of soluble mediators including nitric oxide, transforming growth factor beta, and HLAG5. The MSCs, however, are also able…

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Does the KIR2DS5 gene protect from some human diseases?

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PLoS One. 2010;5(8):e12381 Authors: Nowak I, Majorczyk E, WiÅ›niewski A, Pawlik A, Magott-Procelewska M, Passowicz-MuszyÅ„ska E, Malejczyk J, PÅ‚oski R, Giebel S, Barcz E, ZoÅ„-Giebel A, Malinowski A, Tchórzewski H, Chlebicki A, Łuszczek W, Kurpisz M, GryboÅ› M, WilczyÅ„ski J, Wiland P, Senitzer D, Sun JY, Jankowska R, Klinger M, KuÅ›nierczyk P BACKGROUND: KIR2DS5 gene…

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Targeting improves MSC treatment of inflammatory bowel disease.

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Mol Ther. 2010 Jul;18(7):1365-72. Epub 2010 Apr 13. Targeting improves MSC treatment of inflammatory bowel disease. Ko IK, Kim BG, Awadallah A, Mikulan J, Lin P, Letterio JJ, Dennis JE. Source Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA. Abstract Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is an…

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Microcirculation and tissue regeneration

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Gastroenterology. 2007 Mar;132(3):944-54. Epub 2006 Dec 19. Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease. Khalil PN, Weiler V, Nelson PJ, Khalil MN, Moosmann S, Mutschler WE, Siebeck M, Huss R. Source Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität of München, Munich, Germany. philipe.khalil@med.uni-muenchen.de Abstract BACKGROUND AND AIMS: Reduced microcirculation…

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Ameliorate piroxicam-induced colitis in mice

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Biochem Biophys Res Commun. 2007 Oct 5;361(4):953-9. Epub 2007 Aug 1. Embryonic stem cells ameliorate piroxicam-induced colitis in IL10-/- KO mice. Srivastava AS, Feng Z, Mishra R, Malhotra R, Kim HS, Carrier E. Source Department of Medicine, University of California Irvine, CA 92697, USA. Abstract The primary objective of this work is to determine the…

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Stem cells and complex perianal fistula

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Dis Colon Rectum. 2009 Jan;52(1):79-86. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Garcia-Olmo D, Herreros D, Pascual I, Pascual JA, Del-Valle E, Zorrilla J, De-La-Quintana P, Garcia-Arranz M, Pascual M. Source Department of Surgery and Cell Therapy, La Paz University Hospital, Universidad Autónoma de Madrid, Madrid,…

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Stem cells in intestinal inflammatory diseases

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Ter Arkh. 2010;82(2):38-43. Use of allogeneic mesenchymal stem cells in the treatment of intestinal inflammatory diseases. [Article in Russian] Lazebnik LB, Konopliannikov AG, Kniazev OV, Parfenov AI, Tsaregorodtseva TM, Ruchkina IN, Khomeriki SG, Rogozina VA, Konopliannikova OA. Abstract AIM: to determine the whether mesenchymal stem cells (MSC) may be used in the treatment of patients…

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Risk reduction in ulcerative colitis relapse

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Eksp Klin Gastroenterol. 2010;(3):5-10. Transplantation of allogeneic mesenchymal stem cells from the bone marrow increases duration of remission and reduces the risk of ulcerative colitis relapse. [Article in Russian] Lazebnik LB, Kniazev OV, Parfenov AI, Ruchkina IN, Rogozina VA, Konopliannikov AG. Abstract The first results of allogeneic mesenchymal stem cells from the bone marrow transplantation…

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Severe anti-TNF refractory Crohn disease

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Blood. 2010 Dec 23;116(26):6123-32. Epub 2010 Sep 13. Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up. Burt RK, Craig RM, Milanetti F, Quigley K, Gozdziak P, Bucha J, Testori A, Halverson A, Verda L, de Villiers WJ, Jovanovic B, Oyama Y. Source Division of Immunotherapy, Department of…

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