Braz J Med Biol Res. 2007 Dec;40(12):1579-97 The use of stem cells for the treatment of autoimmune diseases. Authors: Rosa SB, Voltarelli JC, Chies JA, Pranke P Autoimmune diseases constitute a heterogeneous group of conditions commonly treated with anti-inflammatory, immunosuppressant and immunomodulating drugs, with satisfactory results in most cases. Nevertheless, some patients become resistant to…

Hematology. 2007 Jun;12(3):179-91 Haemopoietic stem cell transplantation–an evolving treatment for severe autoimmune and inflammatory diseases in rheumatology, neurology and gastroenterology. Authors: Kapoor S, Wilson AG, Sharrack B, Lobo A, Akil M, Sun L, Dalley CD, Snowden JA The concept of haemopoietic stem cell transplantation (HSCT) to treat severe autoimmune diseases has been around for several…

Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks. Tyndall A, Uccelli A. Source Department of Rheumatology, University of Basel, University Rheumatology Clinic, Basel, Switzerland. alan.tyndall@fps-basel.ch Abstract MSCs, otherwise known as multipotent mesenchymal stromal cells, are being examined for the treatment of autoimmune disease (AD) on the basis of their in vitro…

Rheumatology (Oxford). 2006 Oct;45(10):1187-93 Adult stem cells in the treatment of autoimmune diseases. Authors: van Laar JM, Tyndall A During the past 10 yrs, over 700 patients suffering from severe autoimmune disease (AD) have received an autologous haematopoietic stem cell transplant as treatment of their disorder with durable remission being obtained in around one-third. The…

Ann N Y Acad Sci. 2007 Sep;1110:455-64 Autologous stem cell transplantation for severe autoimmune diseases: a 10-year experience. Authors: Gualandi F, Bruno B, Van Lint MT, Luchetti S, Uccelli A, Capello E, Mancardi GL, Bacigalupo A, Marmont A The first autologous hematopoietic stem cell transplantation in Europe for a patient with severe refractory systemic lupus…

Zhonghua Nei Ke Za Zhi. 2007 Dec;46(12):1018-21 Immunoregulatory effect of bone marrow mesenchymal stem cells on regulatory T cells in patients with systemic lupus erythematosis  Authors: Sun Y, Zhang FS, Zhang ZY OBJECTIVE: To study the in vitro modulation of autogeneic and allogenic regulatory T lymphocytes proliferation by bone marrow mesenchymal stem cells (MSCs) in…

Medicina (B Aires). 2008;68(2):153-63 Hematopoietic stem cell transplantation in autoimmune diseases Authors: Albarracín F, López Meiller MJ, Naswetter G, Longoni H Transplantation of hematopoietic stem cells, which are capable of self renewal and reconstitution of all types of blood cells, can be a treatment for numerous potential lethal diseases, including leukemias and lymphomas. It may…

Immunol Res. 2008;41(1):79-86 Autoimmune disease: is it a disorder of the microenvironment? Authors: El-Badri NS, Hakki A, Ferrari A, Shamekh R, Good RA Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease that involves several vital organs including the cardiovascular system, joints, and kidneys. The pathology is characterized by accumulation of autoreactive lymphocytes that…

Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Yoshimura K, Sato K, Aoi N, Kurita M, Inoue K, Suga H, Eto H, Kato H, Hirohi T, Harii K. Source Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan. yoshimura-pla@h.u-tokyo.ac.jp Abstract BACKGROUND: Lipoinjection is a promising treatment, but…

Cell Mol Immunol. 2008 Dec;5(6):417-24. Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice. Zhou K, Zhang H, Jin O, Feng X, Yao G, Hou Y, Sun L. Source Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China. Abstract Recent evidence…