by Tracy S. P. Heng, Jarrod A. Dudakov, Danika M. P. Khong, Ann P. Chidgey & Richard L. Boyd Published – October 2009 Stem cells – meet immunity Abstract The ability of stem cells to differentiate into various different cell types holds great promise for the treatment of irreversible tissue damage that occurs in many…

Na Li & Jinlian Hua Published – February 2017 Interactions between mesenchymal stem cells and the immune system Abstract In addition to being multi-potent, mesenchymal stem cells (MSCs) possess immunomodulatory functions that have been investigated as potential treatments in various immune disorders. MSCs can robustly interact with cells of the innate and adaptive immune systems,…

Mohamad R. Issa, Ahmad S. Naja, Nour Z. Bouji and Bernard H. Sagherian Published – November 2022 The role of adipose-derived mesenchymal stem cells in knee osteoarthritis: a meta-analysis of randomized controlled trials Abstract Background: Adipose-derived mesenchymal stem cells (ADMSCs) have recently been studied for the treatment of knee osteoarthritis. The goal is pain reduction…

Yu-Xin Liu, Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Dong-Sheng Wen, Yang-Dan Liu, Lu Huang, Yi-Fan Zhang Published – May 2023 Advancements in adipose-derived stem cell therapy for skin fibrosis Abstract Pathological scarring and scleroderma, which are the most common conditions of skin fibrosis, pathologically manifest as fibroblast proliferation and extracellular matrix (ECM) hyperplasia. Fibroblast proliferation…

Ruijiao Tian, Shibo Su, Yang Yu, Siqiang Liang, Chuqing Ma, Yang Jiao,Weihong Xing, Ziheng Tian, Tongmeng Jiang, Juan Wang Published – April 2024 Revolutionizing osteoarthritis treatment: How mesenchymal stem cells hold the key Abstract Osteoarthritis (OA) is a multifaceted disease characterized by imbalances in extracellular matrix metabolism, chondrocyte and synoviocyte senescence, as well as inflammatory…

Yang Song, Hui Du, Chengxiang Dai, Li Zhang, Suke Li, David J Hunter, Liangjing Lu, Chunde Bao Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections Abstract Aim: This study aimed to evaluate the safety and therapeutic potential of autologous human adipose-derived mesenchymal stem cells (haMSCs) in patients…

by Rui-Cheng Zhang, Wen-Qi Du, Jing-Yuan Zhang, Shao-Xia Yu, Fang-Zhi Lu, Hong-Mei Ding, Yan-Bo Cheng, Chao Ren, De-Qin Geng Published – March 2021 Mesenchymal Stem Cell Treatment for Peripheral Nerve Injury: A Narrative Review Abstract Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of life. The peripheral nervous…

by Portland Press Ltd Published – August 2021 Stem cells and regenerative medicine in sport science The estimated cost of acute injuries in college-level sport in the USA is ∼1.5 billion dollars per year, without taking into account the cost of follow up rehabilitation. In addition to this huge financial burden, without appropriate diagnosis and…

by Maura Faraci, Gianluca Dell’Orso, Stefano Giardino, Filomena Pierri Published – May 2022 Autoimmune diseases after allogeneic stem cell transplantation: a clinician’s guide and future outlook Abstract Introduction: Autoimmune disease (AD) may occur after allogeneic hematopoietic stem cell transplantation (HSCT). The autoimmune mechanism seems to be related to an imbalance of the immune regulation effect…

by Basem Ali Zogel, Hussam Masoud Darraj, Zenat Ahmed Khired, Fahad Yahya AlArishi Published – July 2023 Utilizing mesenchymal stem cells to improve the healing process of the medial collateral ligament in the knee Abstract The healing process of the medial collateral ligament (MCL) in the knee is often slow, resulting in adverse outcomes such…