• After the Covid pandemic, we have resumed stem cell treatments. Appropriate sterility and great care in sanitisation is undertaken as usual. If you are unwell with a cough cold or respiratory symptoms it is best to postpone your procedure.

Prospective Study of Autologous Adipose Derived Stromal Vascular Fraction Containing Stem Cells for the Treatment of Knee Osteoarthritis

150 150 NZ Stem Cell Treatment Centre

Int J Stem Cell Res Ther 2019, 6:064

Prospective Study of Autologous Adipose Derived Stromal Vascular Fraction Containing Stem Cells for the Treatment of Knee Osteoarthritis

Mark Berman, MD*, Elliot Lander, MD, Thomas Grogan, MD, Walter O’Brien, MD, Jonathan Braslow, MD, Shawntae Dowell and Sean Berman, MS

Cell Surgical Network, University of Southern California, USA

 

ABSTRACT

Background

The management of osteoarthritis of the knee runs the spectrum of care from a variety of conservative treatments often culminating in total joint arthroplasty. We initiated a large prospective study to evaluate whether autologous adipose derived stromal vascular fraction (SVF – rich in stem cells) therapy is a safe and effective option.

Methods

A patient funded prospective study of 2,586 patients from a network of physicians participated in an IRB approved study using autologous stromal vascular fraction SVF (ClinicalTrials.gov as NCT10953523). All patients were treated with a standardized surgical protocol to harvest lipoaspirate, isolate and deploy autologous SVF. Data was collected using an online registry and patients were followed-up via an automatic online database collection service.

Results

2,586 patients were treated. Statistically significant improvement was seen at 1 and 2 years – meaning less pain and greater ease of mobility. There was no difference between male or female outcomes (82% overall improvement). All BMI levels showed improvements though higher BMIs had less improvement. There was no difference in outcomes between SVF alone or with PRP added to SVF. Improvement was the same regardless of payment or receiving free care. There were very few adverse events and those that did occur were largely very minor or easily treatable.

Conclusion

Deployment of autologous SVF represents a simple surgical procedure that can be safely performed in an adequate outpatient environment under straight local anesthesia and demonstrates very good outcomes even in difficult cases of chronic knee arthritis.

To read the full article, click here DOI: 10.23937/2469-570X/1410064

Related: Prospective Study of Autologous Adipose; Autologous Adipose; autologous SVF; Treatment of Knee Osteoarthritis; Stem Cells Treatment of Knee Osteoarthritis; ; Stem cells; Stromal vascular fraction.